Federal drug policy needs a major overhaul, but Rahul Gupta has a record of making harmful compromises.

Both coffee and opium come from plants. Why embrace one and not the other?

An internet huckster got rich selling a sex enhancement supplement named Stiff Nights. Then the FDA sampled his wares.

The line between legal pharmaceuticals and illegal drugs has less to do with science than with race, class, and gender.

They seeded medical breakthroughs and emerging markets. Now expunge their criminal records and let them go legit.

Traditional treatments often take place in expensive facilities, demand total abstinence, and rely on punitive methods of control. A harm reduction model turns all of that on its head.

How the seizure of Europe's largest heroin shipment created bloody fallout throughout the world—and sparked still-raging political corruption scandals in Turkey, Greece, and the Middle East

“Any gains we made in funding for health departments, syringe exchanges, naloxone distribution—it’s all at risk.”

Netflix’s documentary captures the newfound acceptability of mind-altering substances.

From alcohol to amphetamines, a new book shows intimate links between the policing of substances and the waging of war.

The progressive prosecutor wants to fight gun violence with a light touch. His critics say he’s crazy. His defenders say he’s onto something.

The paper's otherwise stellar investigative journalism accidentally exposes the failed Beltway consensus.

The controversial proposed deal with Purdue Pharma hints at better alternatives to for-profit pharmaceutical companies.

Or are they just looking to cut a deal for the sake of cutting a deal?

Two new movies reveal the strengths and weaknesses of the film industry's attempts to tackle America's addiction crisis.

Andrés Manuel López Obrador won in a landslide on Sunday. At the heart of his platform: forgiveness for drug offenses and a national reconciliation effort. Can it work?

To understand the Iván Duque Márquez victory this weekend, you need to understand the man behind him: former president Álvaro Uribe Vélez.

Much has been made of the very real woes of American workers. But Mexicans are trapped in an especially brutal cycle of dependence and exile.

America came close to legalizing marijuana in the 1970s. What went wrong?

Stripped of the region’s coal and ravaged by drugs, the people of Appalachia are fighting to survive.